Mechanisms and Prospects of EGCG in the Prevention and Treatment of Atheroscle-rosis
10.20039/j.cnki.1007-3949.2025.09.009
- VernacularTitle:EGCG在动脉粥样硬化防治中的作用机制及展望
- Author:
Xueqi DAI
1
;
Guanjie ZHANG
;
Jing LI
;
Huiyu LONG
;
Hui SUN
Author Information
1. 南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技创新合作基地;南华大学衡阳医学院公共卫生学院
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
epigallocatechin-3-O-gallate;
mechanisms of action;
cardiovascular diseases
- From:
Chinese Journal of Arteriosclerosis
2025;33(9):803-809
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(As)is a chronic inflammatory vascular disease and serves as the pathological basis for various cardiovascular diseases.Epigallocatechin-3-O-gallate(EGCG)is the most abundant and biologically active com-pound in green tea,possessing multiple pharmacological effects such as anti-inflammatory,antiviral,and antioxidative stress properties.In recent years,studies have found that EGCG can regulate lipid metabolism,improve vascular endo-thelial function,and enhance plaque stability,demonstrating its potential value in combating As.This article provides a systematic review of the mechanisms underlying EGCG's anti-As effects,aiming to offer multi-faceted theoretical support for its further research and clinical application in the prevention and treatment of As.
