Serum Gal-3,sST2,ProDH levels and their clinical significance in elderly patients with heart failure
10.20039/j.cnki.1007-3949.2025.09.006
- VernacularTitle:老年心力衰竭患者血清Gal-3、sST2和ProDH水平及其临床意义
- Author:
Yapeng LI
1
Author Information
1. 郑州大学第一附属医院,河南省郑州市 450052
- Publication Type:Journal Article
- Keywords:
heart failure;
galectin-3;
soluble suppression of tumorigenicity 2;
proline dehydrogenase;
prog-nosis
- From:
Chinese Journal of Arteriosclerosis
2025;33(9):781-788
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the levels and clinical significance of serum galectin-3(Gal-3),soluble sup-pression of tumorigenicity 2(sST2)and proline dehydrogenase(ProDH)in elderly patients with heart failure.Meth-ods Using a single-center retrospective cohort study design,165 elderly patients with heart failure who were diagnosed and treated in our hospital from January 2022 to October 2023 were selected as the observation group,and 120 elderly patients with normal cardiac function and no heart disease who underwent physical examination in our hospital during the same peri-od were selected as the control group.Serum Gal-3,sST2,and ProDH levels were compared between the two groups.The ROC curve was drawn to analyze the diagnostic value of Gal-3,sST2 and ProDH levels in elderly patients with heart failure.Spearman rank correlation was used to analyze the correlation between Gal-3,sST2,ProDH and heart failure in the elderly.At the same time,the observation group was divided into a poor prognosis group(n=49)and a good progno-sis group(n=116)according to the prognosis.The general data of the two groups were compared.The associated risk factors influencing the poor prognosis of elderly heart failure were examined using Logistic regression model.ROC curve was created to examine the predictive value of associated risk factors for a poor prognosis of elderly heart failure.Re-sults The levels of Gal-3 and sST2 were significantly higher in observation group than those in control group,the level of ProDH was significantly lower than in control group,with statistical significance(P＜0.05).ROC curve results showed that Gal-3,sST2,ProDH and combined diagnosis were statistically significant for the diagnosis of heart failure in the elder-ly(P＜0.05).The AUC of the combined diagnosis was 0.996,95％CI was 0.992～1.000,the sensitivity was 0.970,the specificity was 0.975,and the diagnostic value was higher.Spearman rank correlation analysis showed that Gal-3 and sST2 were positively correlated with heart failure in the elderly(P＜0.05),and ProDH was negatively correlated with heart failure in the elderly(P＜0.05).Multivariate analysis of Logistic regression model showed that NYHA cardiac function grade IV,high level of Gal-3 and high level of sST2 were independent risk factors for poor prognosis of elderly patients with heart failure(P＜0.05),and elevated left ventricular ejection fraction(LVEF)and high level of ProDH were protective factors(P＜0.05).ROC curve results showed that NYHA cardiac function classification,LVEF,Gal-3,sST2,ProDH and combined prediction were statistically significant in predicting the poor prognosis of elderly heart failure(P＜0.05).The AUC of combined prediction was 0.983,95％CI was 0.969～0.998,the sensitivity was 0.939,the specificity was 0.948,and the predictive value was higher.Conclusion In this study,the combined predictive efficacy of Gal-3,sST2 and ProDH was systematically analyzed in elderly patients with heart failure for the first time,and it was found that the combination of the three had significant clinical value in diagnosis and prognosis evaluation.NYHA cardiac function grade Ⅳ,high level of Gal-3 and high level of sST2 were independent risk factors for poor prognosis of elderly patients with heart failure.Elevated LVEF and high level of ProDH were protective factors,all of which have certain predictive value,and the combined predictive value is higher.
