Value of preoperative ultrasound combined with NLR,Ctn and CEA levels in predicting cervical lymph node metastasis of papillary thyroid carcinoma
10.3969/j.issn.1006-5725.2025.18.011
- VernacularTitle:术前超声联合NLR、Ctn、CEA水平预测甲状腺乳头状癌颈侧区淋巴结转移的价值分析
- Author:
Shanshan YAN
1
;
Huiyu ZHANG
;
Jun GU
;
Kan ZHANG
;
Yu ZHAO
Author Information
1. 苏州市立医院 超声科(江苏 苏州 215000)
- Publication Type:Journal Article
- Keywords:
papillary thyroid carcinoma;
cervical lymph node metastasis;
ultrasound;
neutrophil to lymphocyte ratio;
calcitonin;
carcinoembryonic antigen
- From:
The Journal of Practical Medicine
2025;41(18):2859-2864
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of preoperative ultrasound in combination with neutrophil-to-lymphocyte ratio(NLR),calcitonin(Ctn),and carcinoembryonic antigen(CEA)for cervical lymph node metastasis in patients with papillary thyroid carcinoma.Methods A total of 103 patients diagnosed with papillary thyroid carcinoma(PTC)who were admitted to the hospital between October 2021 and October 2024 were selected as the case group.Among them,34 patients with cervical lymph node metastasis confirmed by surgical and pathological examination were assigned to the metastatic group,and 69 patients without cervical lymph node metas-tasis were assigned to the non-metastatic group.Additionally,103 patients with benign thyroid nodules admitted during the same period were enrolled as the control group.Clinical data,ultrasonographic features,and serum levels of NLR,Ctn,and CEA were compared between the metastatic and non-metastatic groups.The predictive value of ultrasonographic features and the combined detection of NLR,Ctn,and CEA levels for cervical lymph node metastasis in PTC was evaluated using receiver operating characteristic(ROC)curve analysis.Results Compared to the control group,the case group exhibited a higher proportion of patients with microcalcification and grade 3 blood flow,as well as elevated levels of NLR,Ctn,and CEA(P<0.05).Similarly,compared to the non-metastatic group,the metastatic group showed a higher proportion of patients with microcalcification and grade 3 blood flow,along with increased levels of NLR,Ctn,and CEA(P<0.05).The metastatic group tested positive,whereas the non-metastatic group tested negative.The area under the curve(AUC)for ultrasound features(micro-calcification,blood flow classification)combined with NLR,Ctn,and CEA levels in diagnosing cervical lymph node metastasis in papillary thyroid carcinoma was higher than that of individual indicators(P<0.05).Conclusions Preoperative ultrasound combined with the assessment of NLR,Ctn,and CEA levels demonstrates significant predictive value for cervical lymph node metastasis in papillary thyroid carcinoma.
