The microbe-immune-virus regulatory network in pediatric asthma:From mechanism to clinic
10.3969/j.issn.1006-5725.2025.20.021
- VernacularTitle:儿童哮喘的微生物-免疫-病毒调控网络:从机制到临床
- Author:
Xu QIN
1
;
Lihong SUN
1
Author Information
1. 广州医科大学附属第一医院小儿呼吸科,国家呼吸医学中心,呼吸疾病全国重点实验室,广州呼吸健康研究院(广东 广州 510163)
- Publication Type:Journal Article
- Keywords:
childhood asthma;
early life;
microbe-immune network;
gut-lung axis;
precision medicine
- From:
The Journal of Practical Medicine
2025;41(20):3297-3304
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric asthma is a complex and heterogeneous disease,with susceptibility in early life co-shaped by the interplay of host genetics,environmental exposures,microbial colonization,and immune development.Early-life airway viral infections are a well-established risk factor,though their pathogenic effects are highly host-dependent.Emerging evidence indicates that the gut microbiome remotely regulates pulmonary immune homeostasis via metabolites such as butyrate(the gut-lung axis),playing a pivotal role in the disease trajectory.Multi-omics research has expanded the scope of this regulatory network,identifying cross-kingdom microbial members,including the gut virome(phages)and protozoa.These members influence asthma susceptibility by activating specific immune pathways,such as the Tfh13-IgE axis and innate immune memory.Crucially,many children exposed to risk factors remain healthy,highlighting the roles of individual resilience and protective factors.Elucidating this network is crucial for clarifying disease heterogeneity and provides a basis for developing novel biomarkers(e.g.,the oropharyngeal microbiome,serum Extracellular Vesicles[EVs])and constructing multi-dimensional risk prediction models integrating artificial intelligence.This research ultimately aims to advance personalized precision prevention and management for pediatric asthma.
