Anxiety and depression,gut microbiota,and constipation
10.3969/j.issn.1005-6483.20250894
- VernacularTitle:焦虑抑郁、肠道菌群与便秘
- Author:
Shuo ZHANG
1
;
Yijun LI
;
Cailing WEI
;
Yiyang WANG
;
Xiancang MA
;
Lie YANG
;
Feng ZHU
Author Information
1. 710061 陕西西安,西安交通大学第一附属医院脑科学研究中心
- Publication Type:Journal Article
- Keywords:
constipation;
anxiety and depression;
gut microbiota;
microbiota-gut-brain axi
- From:
Journal of Clinical Surgery
2025;33(8):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Constipation,a common functional gastrointestinal disorder,not only severely impairs patients'quality of life but is also highly comorbid with psychiatric conditions such as anxiety and depression.Emerging evidence indicates that gut microbiota dysbiosis is a critical link connecting these two disease states.On one hand,dysbiosis exacerbates constipation by affecting host metabolism and intestinal function;on the other,it plays a central role in the pathophysiology of mood disorders.This complex interaction is primarily mediated through the"microbiota-gut-brain axis."Therefore,elucidating the intrinsic relationship among anxiety,depression,gut microbiota,and constipation has become a frontier of interdisciplinary research.
