Researchers Achieve a Major Breakthrough in the Field of Homologous Recombination Research in Meiosis
10.13865/j.cnki.cjbmb.2025.07.1168
- VernacularTitle:科学家在减数分裂同源重组研究领域取得突破性进展
- Author:
Mei MA
1
;
Wen-Qing SHI
Author Information
1. 齐鲁师范学院生命科学学院植物生物学教研室,济南 250200
- Publication Type:Journal Article
- Keywords:
meiosis;
homologous recombination;
DNA double-strand break(DSB);
SPO11(sporula-tion protein11)-TOP6BL(TOP6B like)complex
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(9):1239-1242
- CountryChina
- Language:Chinese
-
Abstract:
Homologous recombination is a crucial biological event during meiosis,and its initial step in-volves the formation of programmed DNA double-strand break(DSB).However,for a long time,how to reconstitute the process of meiotic DSB formation in vitro remained an unresolved challenge in the scien-tific community.Recently,scientists have achieved a breakthrough.For the first time,they successfully reconstructed the formation of meiotic DSB in vitro.The findings reveal that weak dimerization is a key characteristic of the SPO11(sporulation protein11)-TOP6BL(TOP6B like)core complex.In vivo,the activity of SPO11 may be limited by its intrinsically weak dimerization ability.This discovery suggests that the dimerization process of SPO11 plays a vital role in regulating meiotic DSB formation.This a-chievement not only fills a gap in related research fields but also provides critical insights into the molecu-lar mechanism of meiotic DSB formation.Moreover,it offers important directions and implications for fu-ture studies in this field.
