Design and Synthesis of Tumor mRNA Vaccines
10.13865/j.cnki.cjbmb.2025.07.1115
- VernacularTitle:肿瘤mRNA疫苗的设计与合成
- Author:
Man-Xin DU
1
;
Guo-Dong YANG
1
;
Jing ZHAO
1
Author Information
1. 空军军医大学基础医学院生物化学与分子生物学教研室,西安 710032
- Publication Type:Journal Article
- Keywords:
mRNA vaccine;
tumor antigen;
sequence design;
circular RNA(circRNA);
RNA delivery
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(9):1235-1238
- CountryChina
- Language:Chinese
-
Abstract:
The development of tailor-made tumor vaccines targeting specific tumor antigens is crucial for improving treatment accuracy.Tumor mRNA,as an emerging and promising vaccine modality,holds dis-tinct technical edge in addressing this challenge,thus attracting considerable attention in cancer treat-ment.This article reviews the design and synthesis processes of tumor mRNA vaccines,highlighting the latest advances in antigen identification,optimization of RNA sequence and structure,and its delivery.Additionally,it discusses the challenges these vaccines face and outlines potential future directions for development.
