Ferroptosis and Its Potential Targeting Applications
10.13865/j.cnki.cjbmb.2025.06.1046
- VernacularTitle:铁死亡及其潜在的靶向应用
- Author:
Meng-Dan LIU
1
;
Hai-Zhen MO
1
;
Li-Shan YAO
1
Author Information
1. 陕西科技大学 食品科学与工程学院(生物与医药学院)食品科学与工程系,西安 710021
- Publication Type:Journal Article
- Keywords:
ferroptosis;
inhibitors;
targeted therapy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(9):1268-1279
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis,a novel form of programmed cell death driven by iron-dependent lipid peroxida-tion,plays a crucial role in both disease treatment and microbial control due to its multi-level regulatory mechanisms.It mainly involves iron metabolism,lipid peroxidation,and antioxidant systems.In the field of disease treatment,ferroptosis is regarded as a highly promising therapeutic target because of its key role in autoimmune diseases,cancer,and cardiovascular diseases.This review systematically summarizes the core regulatory factors of ferroptosis,such as glutathione peroxidase 4(GPX4)and long-chain acyl-CoA synthetase 4(ACSL4)and their interaction networks,and deeply explores the application prospects of targeted intervention strategies based on ferroptosis signaling pathways in disease treatment and micro-bial control.Additionally,we also summarize the current issues faced by ferroptosis in practical applica-tions and proposes strategies,such as nanodelivery,improved drug chemical stability and enhanced water solubility to optimize therapeutic efficacy.We aim to provide a theoretical basis and practical guidelines for exploring more targeted treatments using ferroptosis.
