Function of Obesity in Regulating Reproductive Physiology
10.13865/j.cnki.cjbmb.2025.08.1534
- VernacularTitle:肥胖调控生殖生理功能
- Author:
Cui-Yun MEI
1
;
Ping-Bo YAO
;
Rui CAI
Author Information
1. 西北农林科技大学动物科技学院,陕西省动物遗传育种与繁殖重点实验室,陕西 杨凌 712100
- Publication Type:Journal Article
- Keywords:
obesity;
reproductive impairment;
oxidative stress;
insulin resistance;
adipokine
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(9):1257-1267
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous increase in global obesity prevalence,the impact of obesity on reproduc-tive physiology has garnered widespread societal attention.As a metabolic disorder,obesity is typically accompanied by multiple abnormal physiological phenomena,such as excessive adipose accumulation and exacerbated inflammatory responses,which severely compromise the reproductive health of humans and animals.Reproductive damage induced by obesity involves a series of complex biochemical reactions and in vivo metabolic pathways,manifesting as impaired male sperm quality and female fertility.To better un-derstand the relationship between obesity and reproductive physiology,this review summarizes the repro-ductive injuries caused by obesity and their underlying mechanisms.In the obese state,conditions such as oxidative stress,insulin resistance,and hyperinsulinemia are induced,with adipokines(leptin,adi-ponectin,resistin,etc.)and inflammatory factors(TNF-α,IL-6,IL-1β,etc.)interacting synergisti-cally to affect the reproductive system.Oxidative stress activates the MAPK and NF-κB pathways,inter-fering with insulin signaling,while chronic inflammation leads to adipocyte secretory disorders and dis-rupts the hypothalamic-pituitary-gonadal regulatory axis.Studies have shown that obese males exhibit sig-nificantly decreased testosterone levels and impaired sperm quality,whereas obese females suffer from re-productive hormone imbalance,ovulation disorders,and polycystic ovary syndrome.This review discus-ses how obesity-induced metabolic disorders lead to impaired reproductive physiology in both males and females,along with the underlying mechanisms,providing a theoretical basis for the prevention and treat-ment of obesity-related reproductive disorders in the future.
