Predictive Value of Residual Quantitative Flow Ratio for Long-term Vessel-oriented Composite Endpoints
10.3969/j.issn.1000-3614.2025.09.004
- VernacularTitle:残余定量血流分数对远期血管导向的复合终点的预测价值
- Author:
Rui ZHANG
1
;
Yanpu SHI
;
Changdong GUAN
;
Yanyan ZHAO
;
Shengxian TU
;
Bo YU
;
Guosheng FU
;
Yujie ZHOU
;
Jian'an WANG
;
Yundai CHEN
;
Jun PU
;
Kefei DOU
;
Weixian YANG
;
Yongjian WU
;
Shubin QIAO
;
Lei SONG
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心内科,北京 100037
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
percutaneous coronary intervention;
coronary physiology;
quantitative flow ratio
- From:
Chinese Circulation Journal
2025;40(9):862-869
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the predictive value of residual Murray's law-based quantitative flow ratio(μQFR)on long-term vessel-oriented composite endpoints(VoCE).Methods:This retrospective study included 3 510 patients from the FAVOR Ⅲ China trial.Offline residual μQFR analysis was performed on all vessels(diameter≥2.5 mm)with 50%-90%stenotic lesions.Patients were stratified into high-,intermediate-,and low-risk groups based on residual μQFR tertiles.The primary endpoint was 3-year VoCE,defined as a composite of cardiac death related to the target vessel,target vessel-related spontaneous myocardial infarction,and ischemia-driven target vessel revascularization.Results:Offline analysis was performed on 5 256 vessels from 3 510 patients.The mean residual μQFR was 0.92±0.75.The high-risk group(residual μQFR≤0.91)with 1 554 patients(1 958 vessels);the intermediate-risk group(residual μQFR 0.92-0.96)with 1 211 patients(1 906 vessels);and the low-risk group(residual μQFR>0.96)with 745 patients(1 392 vessels).Over 3-year follow-up,VoCE occurred in 227 vessels(4.3%).The 3-year VoCE incidence was significantly higher in the high-risk group compared to the intermediate-and low-risk groups(6.2%vs.4.1%vs.2.5%,log-rank P<0.001),primarily driven by ischemia-driven target vessel revascularization(5.0%vs.3.0%vs.1.6%,log-rank P<0.001).Hypertension(OR=0.83,95%CI:0.72-0.96),hypercholesterolemia(OR=0.84,95%CI:0.73-0.97),bifurcation lesions(OR=0.72,95%CI:0.63-0.83),moderate/severe calcification(OR=0.70,95%CI:0.57-0.84),and tandem lesions(OR=0.59,95%CI:0.47-0.75)were independent predictors of lower residual μQFR values.Conclusions:Lower residual μQFR is significantly associated with increased VoCE risk during the 3-year follow up period.
