Imaging characteristics of myxofibrosarcoma and correlations with prognosis
10.13929/j.issn.1672-8475.2025.08.010
- VernacularTitle:黏液纤维肉瘤影像学表现及其与预后的相关性
- Author:
Chuanxi HAO
1
;
Dongxu JI
;
Shuo YANG
;
Kunkun SUN
;
Nan HONG
Author Information
1. 北京大学人民医院放射科,北京 100044
- Publication Type:Journal Article
- Keywords:
fibrosarcoma;
tomography,X-ray computed;
magnetic resonance imaging;
prognosis
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(8):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore imaging characteristics of myxofibrosarcoma(MFS)and their correlations with prognosis.Methods Totally 32 patients with pathologically confirmed MFS were retrospectively enrolled and divided into poor prognosis(recurrence/metastasis)group(n=13)and good prognosis group(n=19).Preoperative imaging characteristics of lesions were analyzed and compared between groups,including the location,shape,size,margins,density/signal features of lesions,adjacent bone destruction,peritumoral edema,fascial tail sign,enhancement patterns and tumor vasculature.Results MFS predominantly involved the extremities,especially the lower limbs,and the lesions commonly appeared as iso-to hypodensity masses with internal isodensity fibrous septations on non-enhanced CT.On non-enhanced MRI,MFS commonly demonstrated iso-to hypointense signals on T1WI,markedly hyperintense signals on T2WI,low signal fibrous septa,high signals on diffusion weighted imaging(DWI),as well as tail signs and surrounding soft tissue edema.After administration of contrast agents,solid components of MFS demonstrated marked enhancement.No statistical difference of tumor vascularity was detected between groups(P=0.141,1-β=0.269).Poor prognosis group showed significantly higher rates of diffuse peritumoral edema and fascial tail signs than good prognosis group(both P＜0.05).Conclusion Imaging features of MFS had certain characteristics,and the tail sign and surrounding soft tissue edema were correlated with poor prognosis.
