Contrast-enhanced ultrasound for diagnosing malignant adnexal tumors
10.13929/j.issn.1672-8475.2025.08.009
- VernacularTitle:超声造影诊断附件恶性肿瘤
- Author:
Jun ZHANG
1
;
Liwei HONG
;
Sijie HONG
;
Xiaohong ZHONG
;
Shengli LI
;
Maiguo HU
;
Xiaoqin HE
;
Yanqiu ZHONG
;
Liping ZHONG
Author Information
1. 厦门大学附属妇女儿童医院(厦门市妇幼保健院)超声医学科,福建 厦门 361003
- Publication Type:Journal Article
- Keywords:
adnexa uteri;
contrast-enhanced ultrasound;
carbohydrate antigen 125;
human epididymis protein 4
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(8):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of contrast-enhanced ultrasound(CEUS)for diagnosing malignant adnexal tumors.Methods Totally 112 patients with single adnexal masse were retrospectively enrolled and divided into benign adnexal tumor group(benign group,n=73)and malignant adnexal tumor group(malignant group,n=39).Clinical data,laboratory indicators,ovarian-adnexal ultrasound reporting and data system(O-RADS)classification based on conventional ultrasound(US),CEUS manifestations and CEUS classification of benign and malignant tumors were compared between groups.Multivariable logistic regression analysis of clinical and laboratory indicators being statistically different between groups,as well as US O-RADS classification and CEUS classification was performed to screen the independent predictors of malignant adnexal tumors,and combined models were constructed using forward stepwise regression method.The efficacy of each independent predictor and combined model for diagnosing malignant adnexal tumors was analyzed.Results Statistical differences of carbohydrate antigen 125(CA125),US O-RADS classification,enhancement time and level of CEUS,as well as CEUS classification were found between groups(all P＜0.05).CA125,US O-RADS classification and CEUS classification were all independent predictors of malignant adnexal tumors(all P＜0.05).Combined model Ⅰ,Ⅱ and Ⅲ were constructed based on CA125+CEUS classification,US O-RADS classification+CEUS classification and CA125+US O-RADS classification+CEUS classification,respectively.The area under the curve(AUC)of single CA125 level,US O-RADS classification,CEUS classification and combined model Ⅰ,Ⅱ and Ⅲ for diagnosing malignant adnexal tumor was 0.708,0.809,0.908,0.918,0.945 and 0.954,respectively.AUC of combined model Ⅲ was higher than that of combined model Ⅰ(Z=-2.142,P=0.032),while no significant difference of AUC was found between combined model Ⅱ and Ⅰ nor Ⅱ and Ⅲ(both P＞0.05).Conclusion CEUS could be used to effectively diagnose malignant adnexal tumor.Combining with CA125 level and US O-RADS classification could significantly improve its diagnostic efficacy.
