Research progress on the relationship between triglyceride-glucose-body mass index and atherosclerotic ischemic stroke and its predictive value
10.3969/j.issn.1672-5921.2025.09.008
- VernacularTitle:三酰甘油葡萄糖-体质量指数与动脉粥样硬化性缺血性卒中的关系及其预测价值研究进展
- Author:
Jingyu GU
1
;
Xiangyang TANG
Author Information
1. 241002 安徽省芜湖市,皖南医学院临床医学院
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Ischemic stroke;
Insulin resistance;
Triglyceride-glucose-body mass index;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2025;22(9):644-649
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerotic ischemic stroke is a leading global cause of stroke-related disability and mortality,its pathogenesis is closely linked to insulin resistance(IR).The triglyceride-glucose-body mass index(TyG-BMI),a composite metabolic marker integrating,fasting triglycerides(TG),fasting blood glucose(FBG),and body mass index(BMI),comprehensively reflects IR status through lipotoxicity,glucotoxicity,and obesity.Compared to individual biomarkers(e.g.,TG or FBG alone),TyG-BMI demonstrates superior sensitivity in assessing IR and exhibits strong associations with carotid plaque instability and multisite atherosclerosis.Elevated TyG-BMI levels are associated with an increased risk of atherosclerotic ischemic stroke and are more efficient predictors in Asian populations.This metric offers a novel approach for early risk stratification and personalized management of atherosclerotic ischemic stroke.However,multicenter prospective studies are required to validate causal relationships and elucidate molecular mechanisms underlying its connection with plaque stability and cerebral hemodynamics.Such efforts will refine stroke prevention and treatment strategies based on metabolic biomarkers.This review systematically examines the pathophysiological mechanisms and clinical implications of TyG-BMI in atherosclerotic ischemic stroke.
