Research progress on the mechanism of macrophages in erectile dysfunction
10.13431/j.cnki.immunol.j.20250075
- VernacularTitle:巨噬细胞在勃起功能障碍中的作用机制研究进展
- Author:
Tang TANG
1
;
Yipeng ZHAO
1
;
Tao ZHANG
1
;
Ziyang MA
1
;
Jintao WEI
1
;
Zhiyu WU
1
;
Peihai ZHANG
1
Author Information
1. 成都中医药大学附属医院泌尿外科,成都 610036;代谢性疾病中医药调控四川省重点实验室,成都 610036
- Publication Type:Journal Article
- Keywords:
erectile dysfunction;
macrophages;
immune regulation;
stem cells;
nerve repair;
hormone balance
- From:
Immunological Journal
2025;41(7):519-528
- CountryChina
- Language:Chinese
-
Abstract:
Erectile Dysfunction(ED)is a relatively common clinical condition characterized by male sexual dysfunction.Macrophages,as key components of the immune and inflammatory response systems,play crucial roles in immune surveillance,tissue repair,and the maintenance of tissue homeostasis in processes related to erectile function.Immune inflammation is recognized as one of the pathological factors contributing to ED,and inflammatory markers—including macrophages—are widely believed to be closely associated with the onset of the disorder.This review summarizes the multifaceted roles of macrophages in vascular injury,neural repair,hormonal balance,and immune microenvironment remodeling in the context of erection.It aims to provide a theoretical foundation for further investigation into the involvement of macrophages in ED and discusses the potential of macrophage-targeted therapies for treating ED.
