Association between LIPC-514C/T polymorphism and exercise intervention sensitivity in prediabetes
10.3969/j.issn.1001-1242.2025.10.009
- VernacularTitle:肝脂肪酶基因-514C/T多态性与糖尿病前期人群运动干预敏感性的关联研究
- Author:
Feng CHANG
1
;
Yongle HUANG
1
;
Yue YU
1
Author Information
1. 哈尔滨体育学院,黑龙江省 哈尔滨市,150008
- Publication Type:Journal Article
- Keywords:
hepatic lipase gene;
gene polymorphism;
prediabetes;
exercise sensitivity;
genetic markers
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(10):1510-1518
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between the polymorphism of the hepatic lipase gene(LIPC)and the sensitivity to exercise intervention in the Han Chinese population with prediabetes mellitus(PDM)in the cold northern region of China,and to identify molecular markers related to exercise sensitivity in glucose me-tabolism disorders.Method:From January to September 2022,32 PDM patients were recruited in Harbin sports university,and 40％—59％VO2max aerobic exercise(3 times/week,30-60min/time)combined with 50％—70％1RM elastic band training(2 times/week,15-30 min/time)was performed for 12 weeks.FPG,HbA1c,FINs,TC,TG,HDL-c and LDL-c were measured before and after the intervention,SNP microarray chip was used to analyze the LIPC-514C/T locus in saliva,and SPSS26.0 was used to compare the differences in efficacy indicators among PDM patients with different LIPC-514C/T genotypes.Result:①The CC type of LIPC-514C/T locus accounted for 37.5％,and CT/TT accounted for 62.5％in PDM patients.The gene frequency distribution was consistent with Hardy-Weinberg equilibrium(P>0.05).②The HDL-c level of LIPC-514 CC type in PDM patients was lower than those in CT/TT type,with a signifi-cant difference(P<0.05),while there was no significant difference in other indicators(P>0.05).③After 12-week exercise intervention,the levels of FPG,HbA1c,TC,TG,LDL-c and HOMA-IR were significantly lower(P<0.05),and HDL-c,FINs and HOMA-IS were significantly higher than those before intervention(P<0.05).④The change in FPG,HOMA-IR,TG and HDL-c in CC type PDM patients was significantly higher than those in CT/TT genotype after intervention(P<0.05).Conclusion:A 12-week moderate-intensity aerobic exercise combined elastic band resistance strength training can improve the glucose and lipid metabolism in PDM in cold region.The effect of exercise intervention in re-ducing blood compared to the CT/TT genotype of the LIPC-514C/T locus,which can be used as a molecular marker to evaluate the efficacy of exercise intervention in the Han Chinese population with glucose metabolism disorders in cold region of northern China.
