Characteristics of NK cell immune exhaustion and immunotherapeutic potentia
10.3969/j.issn.1000-484X.2025.10.041
- VernacularTitle:NK细胞免疫耗竭的特征及免疫治疗潜力
- Author:
Yang SHU
1
;
Haina WANG
;
Wen SU
Author Information
1. 山西医科大学第二临床医学院,太原 030013;山西省肿瘤医院医学检验部,太原 030013
- Publication Type:Journal Article
- Keywords:
NK cell;
NK cell exhaustion;
NK cell dysfunction;
Immunotherapy
- From:
Chinese Journal of Immunology
2025;41(10):2554-2560,后插1
- CountryChina
- Language:Chinese
-
Abstract:
NK cells are essential components of innate immune system and play crucial roles in combating tumors and infec-tions by directly eliminating target cells and supporting other immune cells.However,tumors and chronic infections often result in exhaustion of NK cells,which diminishes their effector functions and hampers their ability to control progression of tumors and infec-tions.NK cell exhaustion is accompanied by alterations in surface receptors,cytokines and transcription factors.A comprehensive investigation into characteristics of NK cell exhaustion not only enhances our understanding of fundamental biological properties of NK cells but also facilitates development of novel immunotherapy approaches utilizing NK cells.This article provides an overview of cur-rent understanding of NK cell exhaustion,including its characterization and relevant knowledge,and explores its potential applica-tions in immunotherapy.
