Predictive value of systemic immune inflammation index combined with stress response index for postoperative urinary tract infection in patients with complex kidney stones
10.3969/j.issn.1000-484X.2025.10.029
- VernacularTitle:全身免疫炎症指数联合应激反应指标对复杂肾结石患者术后尿路感染的预测价值
- Author:
Feng WEI
1
;
Guangjun ZHOU
1
;
Shuanghui LI
1
;
Yanyan WANG
1
;
Zhijie JI
1
Author Information
1. 河北省沧州中西医结合医院,沧州 061000
- Publication Type:Journal Article
- Keywords:
Systemic immune-inflammation index;
Complex kidney stones;
Postoperative urinary tract infection;
Predictive value
- From:
Chinese Journal of Immunology
2025;41(10):2482-2487
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of systemic immune inflammation index combined with stress response index for postoperative urinary tract infection in patients with complicated kidney stones.Methods:From June 2021 to June 2023,97 patients who underwent treatment for urinary tract infection after complex kidney stone operation in Cangzhou Hospital of Integrated Traditional and Western Medicine were selected as infected group,and 87 patients who did not develop urinary tract infection after complex kidney stone operation were selected as uninfected group.Systemic immunoinflammatory index(SII),neutrophils,lympho-cyte,platelet,malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT)levels were detected.Multivariate Logistic regression analysis was performed to analyze risk factors of postoperative urinary tract infection,and ROC curve was drawn to analyze the predictive value of SII,MDA,SOD and CAT alone and combined detection for postoperative urinary tract infection in patients with complex kidney stones.Results:Compared with uninfected group,levels of SII,neutrophils and MDA were increased in infected group,while levels of SOD and CAT were decreased(P<0.05).Levels of lymphocytes and platelets were decreased,the difference was not statistically significant(P>0.05).Multivariate Logistic regression analysis showed that presence of urinary tract history,opera-tion time≥100 min,urinary catheter retention time≥7 d,presence of preoperative urinary tract infection,stone load≥1 000 mm2,combined renal dysfunction,and preoperative blood glucose≥6.15 mmol/L were main risk factors for postoperative urinary tract infection in patients with complex kidney stones.ROC curve showed that combined detection was significantly more effective than single detec-tion of SII,MDA,SOD and CAT in the diagnosis of postoperative urinary tract infection in patients with precomplex kidney stones.Conclusion:Patients with urinary tract infection after complicated kidney stones have increased SII and MDA,decreased SOD and CAT levels,and the abnormal increased or decreased expression level are the predictors of risk of urinary tract infection after compli-cated kidney stones,which may be related with the diagnosis,development and prognosis of the disease.
