Risk assessment and mechanistic analysis of gastroesophageal reflux disease and rheumatoid arthritis:A Mendelian randomization and transcriptomics study
10.3969/j.issn.1000-484X.2025.10.017
- VernacularTitle:胃食管反流病和类风湿关节炎的风险评估和机制分析:一项孟德尔随机化和转录组学研究
- Author:
Yifeng XU
1
;
Zhaoqi YAN
;
Keke LI
;
Liangji LIU
Author Information
1. 江西中医药大学,南昌 330000
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux disease;
Rheumatoid arthritis;
Mendelian randomization;
Linkage disequilibrium score regression;
Transcriptional data
- From:
Chinese Journal of Immunology
2025;41(10):2403-2410,中插1-中插14
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal relationship and pathogenesis between gastroesophageal reflux disease(GERD)and rheumatoid arthritis(RA).Methods:Genetic correlation between GERD and RA was evaluated using linkage disequi-librium score regression(LDSC),and potential causal relationship between GERD and RA was analyzed by Mendelian randomization(MR)method.GWAS data for GERD were obtained from the European Bioinformatics Institute,while GWAS data for RA were obtained from the FinnGen consortium and large-scale genome-wide association studies.Transcriptional analysis based on Genecard,DrugBank and GEO databases was then conducted to explore mechanisms of action for GERD and RA,and to identify potential biomarkers.Results:LDSC analysis result showed a genetic correlation between GERD and RA(rg=0.34,P=1.07E-20).Further MR analysis revealed a positive association between GERD and RA risk(OR=1.44,95%CI:1.27～1.63,P=1.17E-08),which was supported by validation data(OR=1.61,95%CI:1.34～1.94,P=3.56E-07).Conversely,there was no evidence to suggest that RA increases the risk of GERD.CXCL10 and EDNRB were identified as potential biomarkers for diagnosing RA in GERD patients.Conclusion:There is a positive causal relationship between GERD and RA,while not vice versa.Transcriptional data analysis indicated that CXCL10 and EDNRB can serve as novel biomarkers for diagnosing RA in GERD patients.
