Causal relationship between IL-7/IL-7Rα and ankylosing spondylitis based on Mendelian randomization
10.3969/j.issn.1000-484X.2025.10.014
- VernacularTitle:基于孟德尔随机化的IL-7和IL-7Rα与强直性脊柱炎的因果关系研究
- Author:
Can WANG
1
;
Yuxin CHEN
;
Jinqi BAI
;
You LI
;
Peifeng HE
;
Qi YU
Author Information
1. 山西医科大学管理学院,太原 030001
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
IL-7;
IL-7 receptor α;
Mendelian randomization
- From:
Chinese Journal of Immunology
2025;41(10):2386-2391
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the causal relationship between IL-7 and IL-7Rα and ankylosing spondylitis(AS)using the Mendelian randomization(MR)method.Methods:This study was based on gene-wide association study(GWAS)summary data,con-structing instrumental variables(IV)using single nucleotide polymorphisms(SNPs).We respectively adopt Inverse variance weighted(IVW),MR-Egger mode and Weighted median(WM)mode to assess the causal relation between IL-7/IL-7Rα and AS.In addition,we also conducted sensitivity tests,including the heterogeneity test,the pleiotropy test,the leave-one-out approach and the MR-PRESSO test.Results:IL-7 and IL-7Rα were respectively included in 9 and 5 IVs that could be used for MR analysis.Results of IVW analysis revealed a reliable causal relationship between IL-7 and IL-7Rα and AS[IL-7:P=0.025 2,OR(95%CI)=0.999 4(0.989 1～0.999 9);IL-7Rα:P=0.008 3,OR(95%CI)=1.000 6(1.000 2～1.001 0)].Cochranes Q test(IL-7:P=0.999 7;IL-7Rα:P=0.946 9)showed that all studies had good homogeneity.The results of a leave-one-out sensitivity analysis suggested that causal associations were not strongly influenced by any selected IVs.The intercept of the MR-Egger regression further showed that pleiotropy did not bias the causal effect in this study.Conclusion:Both IL-7 and IL-7Rα have a strong causal relationship with AS,among which IL-7 is a protec-tive factor for AS,and IL-7Rα is a risk factor for AS.
