Impact of lycopene on myocardial damage in preeclampsia rats by regulating STAT3 signaling pathway
10.3969/j.issn.1000-484X.2025.10.012
- VernacularTitle:番茄红素调节STAT3信号通路对子痫前期大鼠心肌损伤的影响
- Author:
Dongfang LIU
1
;
Yi WANG
;
Senji HAN
;
Lijun SHAO
;
Ningning SUN
;
Zhaobin TANG
Author Information
1. 淄博市第一医院产科,淄博 255200
- Publication Type:Journal Article
- Keywords:
Lycopene;
IL-6/signal transducer and activator of transcription 3/endothelin-1;
Preeclampsia;
Myocardial damage;
Inflammation
- From:
Chinese Journal of Immunology
2025;41(10):2375-2379
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate impacts of lycopene on myocardial damage in preeclampsia(PE)rats by regulating IL-6/signal transducer and activator of transcription 3(STAT3)/endothelin-1(ET-1)signaling pathway.Methods:Pregnant rats were divided into model group,experimental-L group,experimental-M group,experimental-H group,combination group and control group,with 15 rats in each group.PE rat model was established by intraperitoneal injection of 300 mg/kg N-nitro-L-arginine methyl ester(L-NAME)hydrochloride.Experimental-L,experimental-M,experimental-H groups were intraperitoneally injected with 2,4 and 8 mg/kg lycopene,combination group was intraperitoneally injected with 8 mg/kg lycopene and 1 mg/kg STAT3 activator Colivelin,control group and model group were injected with same amount of normal saline intraperitoneally,once a day for 5 consecutive days.Myocardial troponin Ⅰ(cTnⅠ),creatine kinase isozyme(CK-MB)and myoglobin(Mb)levels were detected by ELISA 24 h after the last administration.Western blot was applied to detect IL-6,p-STAT3/STAT3 and ET-1 proteins expressions.Results:Comparison between model group and control group,experimental-L,M,H groups and model group,combined group and high dose experimental group,cTnⅠ,CK-MB,Mb,IL-6 protein,p-STAT3/STAT3 protein,ET-1 protein showed statistically significant differences(all P<0.05).Conclusion:Lycopene alleviates myocardial damage in PE rats by inhibiting IL-6/STAT3/ET-1 signaling pathway.
