Analysis of the association between patent foramen ovale and migraine:advances in biomarker and imaging research
10.3969/j.issn.1004-8812.2025.09.005
- VernacularTitle:卵圆孔未闭与偏头痛相关性分析:生物标志物和影像学研究进展
- Author:
Kai-yuan LIU
1
;
Ji-zhe XU
;
Ming BAI
;
Qiang WANG
;
Li-he YAO
Author Information
1. 兰州大学第一医院(第一临床医学院),甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
Patent foramen ovale;
Migraine;
Biomarkers
- From:
Chinese Journal of Interventional Cardiology
2025;33(9):516-522
- CountryChina
- Language:Chinese
-
Abstract:
Patent foramen ovale(PFO)demonstrates significant comorbidity with migraine,but its causal relationship and the efficacy of transcatheter closure remain controversial.This systematic review examines potential biomarkers and relevant imaging assessments for PFO-associated migraine,aiming to provide a theoretical foundation for clinical diagnosis and treatment.Key biomarkers include platelet activation markers,calcitonin gene-related peptide,homocysteine,and platelet-to-lymphocyte ratio.Imaging evaluations encompass right-to-left shunt grading(transthoracic echocardiography,transcranial Doppler ultrasound),cerebrovascular breath-holding index,characteristics of white matter hyperintensities,alterations in resting-state functional magnetic resonance imaging(rs-f-MRI)brain networks,in-situ thrombi detected by optical coherence tomography,and electroencephalogram(EEG)power spectral features.Research indicates that integrating biomarkers with imaging technologies enhances diagnostic discrimination and treatment outcome prediction.Current challenges include unclear causal relationships and insufficient standardization of detection methods.Future efforts require multidisciplinary collaboration to establish personalized diagnostic and therapeutic frameworks through multimodal indicators,thereby advancing precise prevention and treatment strategies for PFO-related migraine.
