Research Progress on the Molecular Mechanism of Blood-Activating and Stasis-Eliminating Drugs Affecting Tumor Metasta-sis
10.14148/j.issn.1672-0482.2025.1251
- VernacularTitle:活血化瘀药影响肿瘤转移的分子机制研究进展
- Author:
Ziyan ZHU
1
;
Yunxuan ZHU
;
Qiong CHEN
;
Jueyao ZOU
;
Aiyun WANG
;
Yang ZHAO
;
Yin LU
;
Wenx-ing CHEN
Author Information
1. 南京中医药大学药学院,江苏南京 210023
- Publication Type:Journal Article
- Keywords:
blood-activating and stasis-eliminating drugs;
anti-tumor;
tumor metastasis;
angiogenesis;
vascular normalization;
Warburg effect
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(9):1251-1257
- CountryChina
- Language:Chinese
-
Abstract:
The method of promoting blood circulation and removing blood stasis holds a significant position in the theoretical frame-work of traditional Chinese medicine(TCM)for cancer treatment.However,the impact of blood-activating and stasis-eliminating herbs on tumor metastasis remains a subject of clinical uncertainty,which has drawn considerable attention to research on their effects.Based on TCM's understanding of the etiology and pathogenesis of tumors,this article elaborates on the molecular mechanisms through which blood-activating and stasis-eliminating Chinese herbs and their active components influence tumor metastasis.This in-cludes their roles in affecting tumor angiogenesis,inducing normalization of tumor blood vessels,and interfering with the Warburg effect in tumor cells.The findings provide a scientific basis for the anti-tumor theory of the blood-activating and stasis-eliminating ap-proach.
