Research progress on the relationship between Alzheimer's disease and the blood-brain barrier dysfunction
10.3969/j.issn.1004-1648.2025.05.018
- VernacularTitle:Alzheimer's病与血-脑屏障功能障碍的相关性研究进展
- Author:
Shijiao ZHAO
1
;
Bei CHEN
1
;
Yuan TIAN
1
Author Information
1. 065000 河北中石油中心医院全科医学科
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
blood-brain barrier;
pathogenic mechanisms;
pharmacotherapy
- From:
Journal of Clinical Neurology
2025;38(5):385-389
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier(BBB)plays a crucial role in maintaining the special microenvironment of brain tissue,which promotes the exchange of substances while separating the peripheral circulatory system from the brain parenchyma.However,normal aging and neurodegenerative diseases can alter and disrupt the physiological properties of the BBB.This review provides a brief introduction to the interrelationship and pathogenic mechanisms between Alzheimer's disease(AD)and BBB dysfunction,and explores current research status and BBB-targeted pharmacotherapy for AD,providing new ideas for the prevention and treatment of AD.
