The multifaceted role of interleukin-10 in sepsis: from pathophysiology to clinical diagnosis and treatment
10.3760/cma.j.issn.1673-4912.2025.10.014
- VernacularTitle:白细胞介素-10在脓毒症中的多面角色：从病理生理到临床诊疗
- Author:
Yuanxiong ZENG
1
;
Sheng LIN
;
Shibiao WANG
;
Botao NING
Author Information
1. 福建省儿童医院（上海儿童医学中心福建医院），福州 350005
- Publication Type:Journal Article
- Keywords:
Sepsis;
Interleukin-10;
Immunoregulation;
Pathophysiological mechanism;
Clinical translation
- From:
Chinese Pediatric Emergency Medicine
2025;32(10):783-788
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection，with immune dysregulation serving as the central mechanism. Interleukin-10，a pivotal cytokine in the immunopathological cascade of sepsis，plays dual roles in balancing inflammatory and anti-inflammatory responses. This article provided a concise review of the latest research advances regarding the role of interleukin-10 in the pathogenesis，early diagnosis，prognostic evaluation，and therapeutic strategies of sepsis，aiming to enhance clinical understanding of its diagnostic，therapeutic，and prognostic implications in sepsis management.
