Risk factors for early neurological deterioration in patients with acute minor stroke and vertebrobasilar occlusion who received best medical treatment
10.3969/j.issn.1004-1648.2025.05.011
- VernacularTitle:急性椎-基底动脉闭塞性轻型卒中最佳药物治疗后早期神经功能恶化的危险因素
- Author:
Deyang XU
1
;
Zhenghua GU
;
Hui CAO
Author Information
1. 211899 南京市浦口人民医院神经内科
- Publication Type:Journal Article
- Keywords:
minor stroke;
vertebrobasilar;
large vessel occlusion;
neurological deterioration;
risk factors
- From:
Journal of Clinical Neurology
2025;38(5):362-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for early neurological deterioration(END)in patients with acute minor stroke and vertebrobasilar occlusion who received best medical treatment.Methods A total of 114 patients with acute vertebrobasilar artery occlusion and NIHSS score of＜6 were enrolled from a single-center prospective database within 24 h of symptom onset.END was defined as an increase of≥4 points or a ≥ 2 points increase in any single NIHSS item within 72 h stroke onset and exclusion of intracranial haemorrhage.Multivariate Logistic regression analysis was used to identify risk factors associated with END.Results END occurred in 31 patients(27.2％).The age,baseline systolic blood pressure,proportion of proximal vertebrobasilar artery occlusion and time to peak(Tmax)＞6 s volume of patients in the END group were significantly higher than those in the non-END group(all P＜0.05).Multivariate Logistic regression analysis showed that baseline systolic blood pressure,proximal vertebrobasilar artery occlusion and Tmax＞6 s volume were independent risk factors for END in patients with acute vertebrobasilar artery occlusive minor stroke after receiving optimal medical treatment(all P＜0.05).Conclusion In patients with acute minor stroke and vertebrobasilar occlusion who received best medical treatment,baseline systolic blood pressure,proximal vertebrobasilar occlusion,and Tmax＞6 s volume are independent risk factors of END.
