Diagnostic Thresholds of Anti-Müllerian Hormone in Adults with Polycystic Ovary Syndrome and Its Risk Factors for Metabolic Syndrome
10.3969/j.issn.1003-6946.2025.09.017
- VernacularTitle:成人多囊卵巢综合征抗苗勒管激素诊断阈值及并发代谢综合征危险因素分析
- Author:
Chanjuan ZENG
1
;
Yifei HUANG
1
;
An TAN
1
;
Liyuan FENG
1
;
Dan MA
1
;
Minmin HE
1
;
Ying ZOU
1
Author Information
1. 湖南省妇幼保健院妇科内分泌中心,湖南长沙 410028
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Anti-Müllerian hormone;
Threshold;
Metabolic disturbance
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(9):776-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a cutoff level of anti-Müllerian hormone(AMH)which could help with the di-agnosis of polycystic ovary syndrome(PCOS)in adults,and to analyze the risk factors of metabolic syndrome(MS).Methods:A retrospectively analyzed 426 PCOS patients(PCOS group)and 205 healthy controls aged 20-39 years from the Health Checkup Center of the Gynecological Endocrine Center,Hunan Maternal and Child Health Hospital from January 2021 to December 2023.AMH diagnostic validity was estimated by receiver operating characteristic(ROC)curves.Patients were subgrouped into PCOS combined metabolic syndrome group(MS-PCOS)and the uncomplicated MS group(UMS-PCOS)according to metabolic status.Multivariate Logistic regression analysis was performed to determine the risk factors for MS in PCOS patients.Results:The serum AMH level was higher in PCOS group than that in the control group(8.42±3.71 ng/ml vs.2.99±0.94 ng/ml,P＜0.001).AMH cutoff for the diagnosis of PCOS was determined as≥4.87 ng/ml on ROC analysis,and the area under the curve is 0.981 with 92.7％sensitivity and 94.6％specificity.The prevalence of MS was 18.3％(78 ca-ses)in PCOS group.Subgroup analysis showed that MS-PCOS patients had higher waist circumference,BMI,fasting glucose,dyslipidemia,hypertension(BP＞130/85 mmHg),and hormone related index androgen level,but lower AMH vs.UMS-PCOS.Multivariate Logistic regression analysis identified insulin resistance(OR 39.17,95％CI 9.33-164.48),BMI ≥24 kg/m2(OR 3.72,95％CI 1.86-7.45),and hyperandrogenism(OR 2.56,95％CI 1.34-4.89)as independent risk factors of MS.AMH was negatively associated with MS,a single-unit increase in AMH was associated with an 17％decrease in odds of MS(OR 0.83,95％CI 0.73-0.95,P=0.006).Conclusions:Serum AMH levels were significantly higher in adult PCOS patients,with an optimal diagnostic threshold of 4.87 ng/ml.Hyperandrogenism and low AMH levels may predict a higher risk of MS,in addition to metabolism-related factors.
