Clinical Characteristics and Treatment Strategies of Ovarian Sertoli-Leydig Cell Tumors
10.3969/j.issn.1003-6946.2025.09.011
- VernacularTitle:卵巢Sertoli-Leydig细胞瘤临床特征和治疗策略分析
- Author:
Hui SHAO
1
;
Hongyan GUO
;
Huamao LIANG
Author Information
1. 北京大学第三医院妇产科,北京 100191;国家妇产疾病临床医学研究中心,北京 100191
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Sertoli-Leydig cell tumors;
Pathological diagnosis;
Surgery;
Chemotherapy
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(9):743-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics and the treatment strategies of surgery and post-operative chemotherapy of ovarian Sertoli-Leydig cell tumors.Methods:A total of 18 patients who underwent sur-gical treatment in Department of Gynecology,Peking University Third Hospital from January 2003 to June 2022 and were pathologically diagnosed with ovarian Sertoli-Leydig cell tumors were selected as the research subjects.The clinical manifestations,auxiliary examinations,surgical and pathological diagnoses,adjuvant treatments and fol-low-up of the included patients were retrospectively analyzed.Results:The age of onset ranged from 19 to 59 years old,with a median age of 24 years old.Among them,12 cases(66.7％)were under40 years old.11 cases(61.1％)showed abnormal symptoms of sex hormones,such as hyperandrogenism and menstrual disorders,and 6 cases(33.3％)sought medical attention for acute abdomen.Preoperative ultrasound indicated a single non-sim-ple mass in the pelvic cavity in 17 cases,during the operation,all tumors were found to originate from one ovary,and all patients under the age of 40(12 cases)underwent adnexectomy on the affected side to preserve fertility.The accuracy of intraoperative frozen pathology was 31.3％(5/16).Among the 18 patients,11 cases were in stage ⅠA and 7 in stage ⅠC,1 case was of well-differentiated type,10 cases of moderate differentiation and 7 ca-ses of poorly differentiated type,3 cases had heterogeneous components.12 cases received adjuvant chemother-apy after surgery.After initial treatment,follow-up was conducted for 4 to 230 months,with a median time of 70.5 months.One case of high-grade sarcoma with heterologous components experienced multiple recurrences,the others had no recurrence.Conclusions:Most cases of ovarian Sertoli-Leydig cell tumors are diagnosed as stageⅠ.For young patients,adnexectomy on the affected side can be performed to preserve fertility and have a good prognosis.But if the tumor contains heterologous components as high-grade sarcoma,it indicates a poor prognosis.
