Prognostic factors of moderate to severe traumatic brain injury in children
10.3760/cma.j.issn.1673-4912.2025.10.011
- VernacularTitle:儿童中重度创伤性颅脑损伤预后因素分析
- Author:
Yuanyuan CHEN
1
;
Xiaoping RAO
1
;
Tao WU
1
;
Weiping WU
1
;
Yourong ZHU
1
Author Information
1. 江西省儿童医院PICU，南昌 330006
- Publication Type:Journal Article
- Keywords:
Traumatic brain injury：Prognosis;
BIG score;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(10):769-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between clinical symptoms，BIG score，laboratory examination and the prognosis of children with moderate to severe traumatic brain injury (TBI)，to determine the indicators associated with poor prognosis，in order to make early judgment for the prognosis of children with moderate to severe TBI.Methods:A total of 78 children with moderate to severe TBI were enrolled in the PICU of Jiangxi Provincial Children's Hospital from January 2022 to January 2023. Clinical data，laboratory tests，BIG scores and Glasgow prognostic score were collected upon admission. The patients were followed up for 6 months and divided into poor prognosis group（Glasgow prognostic score1-3）and good prognosis group（Glasgow prognostic score4-5）based on the Glasgow prognostic score. The indicators related to poor prognosis were selected，and the efficacy of the indicators to predict the prognosis was analyzed and compared.Results:There were statistical differences among BIG score，hemoglobin，lactic acid，glucose，respiratory failure，and hypotension shock（ P<0.05）. The BIG score was an independent risk factor for a poor prognosis. The BIG score had the highest AUC value（0.820）among the four indices. The combined indices（BIG score，hemoglobin，lactic acid，glucose）had the highest AUC value（0.851）and had better performance for predicting the prognosis of moderate to severe TBI in children than any of the four indexs alone. Conclusion:The BIG score can be an independent predictor of early outcome in children with moderate to severe TBI. The combination of BIG score，hemoglobin，lactic acid，and glucose has better performance for predicting the prognosis of moderate to severe TBI in children than any of the four indices alone.
