Research progress in molecular mechanisms of cellular senes-cence and in traditional Chinese medicine intervention strategies for chronic kidney disease
10.3867/j.issn.1000-3002.2025.08394
- VernacularTitle:慢性肾病中细胞衰老的分子机制及中医药干预策略研究进展
- Author:
Yiming LIU
1
;
Jiale WEI
;
Liu LIU
;
Changyu LI
Author Information
1. 浙江中医药大学药学院,浙江 杭州 311402
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
cellular senescence;
cell cycle;
senescence-associated secre-tory phenotype;
mitochondrial dysfunction;
traditional Chinese medicine;
active ingredient
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(9):703-710
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease(CKD),a major threat to global public health,exhibits disease progression closely linked to renal cellular senescence.This review outlines the key molecular mecha-nisms underpinning cellular senescence in CKD,including mitochondrial dysfunction,DNA damage response,senescence-associated secretory phenotype,and the central role of epigenetic regulation.Furthermore,the advances in traditional Chinese medicine(TCM)for mitigating renal senescence through multi-target strategies such as oxidative stress inhibition,anti-inflammatory modulation,and interventions in cell cycle arrest are summarized.There is evidence that active TCM compounds and formulas exert anti-senescence potential by modulating pathways including sirtuin 1/PTEN induced kinase 1 and Wnt/β-catenin signaling.However,clinical translation remains constrained by a poor knowledge of the mechanisms,challenges to dose standardization,and a lack of clinical validation.Future studies should integrate kidney-specific transgenic models with single-cell omics to resolve the cell hetero-geneity of senescence while developing novel delivery systems to enhance the targeting efficiency of TCM components so as to facilitate precision interventions in CKD.
