Research progress in hepatotoxicity of toxic traditional Chinese medicines in 2025 edition of Pharmacopoeia of the People's Republic of China
10.3867/j.issn.1000-3002.2025.07963
- VernacularTitle:《中华人民共和国药典》2025版有毒中药肝毒性研究进展
- Author:
Lin XU
1
;
Qiuyu HUANG
;
Dongmei YAN
Author Information
1. 广州珠江职业技术学院医药健康学院,广东 广州 511300;江西中医药大学院士工作站,江西南昌 330004
- Publication Type:Journal Article
- Keywords:
Pharmacopoeia of the People's Republic of China;
toxic Chinese herbal medicine;
hepatotoxicity;
action mechanism;
drug safety;
research progress
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(9):689-702
- CountryChina
- Language:Chinese
-
Abstract:
Toxic Chinese herbal medicines(TCHMs)both represent a unique class of therapeutic agents that exhibit both potent efficacy("using toxins to combat pathogens and often curing critical con-ditions")and pose safety concerns("potentially causing severe harm").Balancing clinical effectiveness with safe applications remains a priority of research for these substances.This review summarizes the hepatotoxic mechanisms,research progress,detoxification strategies and clinical challenges associated with TCHMs documented in the 2025 Pharmacopoeia of the People's Republic of China(Volume Ⅰ)in the hope of providing evidence-based insights into the safe and rational clinical use of these hepatotoxic herbs.
