Analysis of changes in serum C1q tumor necrosis factor-related protein 12,adiponectin,and resistin levels in patients with type 2 diabetes mellitus and hypertension with different grades and its influencing factors
10.3969/j.issn.1006-6187.2025.09.010
- VernacularTitle:不同高血压分级2型糖尿病患者血清C1q肿瘤坏死因子相关蛋白12、脂联素、抵抗素水平变化及影响因素的研究
- Author:
Xi YANG
1
;
Chao YIN
1
;
Xin ZHANG
1
;
Dongxun ZHANG
1
Author Information
1. 071000 保定市第一中心医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Hypertension;
C1q tumor necrosis factor-related protein 12;
Adiponectin;
Resistin
- From:
Chinese Journal of Diabetes
2025;33(9):687-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significance of serum C1q tumor necrosis factor-related protein 12(CTRP12),adiponectin(APN),and resistin(RETN)in patients with type 2 diabetes mellitus(T2DM)combined with different grades of hypertension.Methods A total of 156 patients with T2DM were selected and divided into the following groups:isolated T2DM group(T2DM,n=38),T2DM combined with hypertension grade 1(DH1,n=39)group,T2DM combined with hypertension grade 2(DH2,n=39)group,and T2DM combined with hypertension grade 3(DH3,n=40)group.Additionally,healthy individuals who underwent physical examinations at our hospital were selected as the normal control(NC,n=40)group.Serum levels of CTRP12,APN,and RETN were measured using ELISA.Pearson correlation analysis was used to evaluate the relationship between serum CTRP12,APN,RETN,and other indicators.Multiple linear regression analysis was performed to determine the influencing factors for the three indicators.Results In NC,T2DM,DH1,DH2 and DH3 groups,DBP increased in turn(P<0.05),while CTRP12 decreased in turn(P<0.05).SBP in T2DM,DH1,DH2 and DH3 groups increased in turn(P<0.05).In DH1,DH2 and DH3 groups,RENT increased in turn(P<0.05),while APN decreased in turn(P<0.05).Pearson correlation analysis showed that serum CTRP12 was negatively correlated with WHR,BMI,HOMA-IR,FPG,HbA1c,FIns,TC,LDL-C,SBP,and DBP(P<0.05).Serum APN was negatively correlated with BMI,FPG,HbA1c,FIns,TC,SBP,and DBP(P<0.05),and positively correlated with HDL-C(P<0.05).Serum RETN was positively correlated with WHR,HOMA-IR,FPG,HbA1c,FIns,SBP,and DBP(P<0.05).Multiple linear regression analysis indicated that SBP was an influencing factor for CTRP12 and RETN,while SBP and HbA1c were influencing factors for RETN.Conclusions In patients with T2DM combined with hypertension,serum CTRP12 and APN levels decrease,while RETN levels increase,with significant changes observed as HP grades increase,suggesting that these three factors may collectively influence the occurrence and development of T2DM combined with HP.
