Research on the correlation between early nutrition and bronchopulmonary dysplasia in very preterm infants
10.3760/cma.j.issn.1673-4912.2025.10.007
- VernacularTitle:极早产儿早期营养与支气管肺发育不良的相关性研究
- Author:
Xiaoting BAI
1
;
Hua MEI
Author Information
1. 内蒙古包钢集团第三职工医院新生儿科，包头 014000
- Publication Type:Journal Article
- Keywords:
Nutrition;
Preterm infants;
Bronchopulmonary dysplasia;
Calorie
- From:
Chinese Pediatric Emergency Medicine
2025;32(10):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between enteral and parenteral nutrition intake in very preterm infants during the first week after birth and the development of bronchopulmonary dysplasia (BPD).Methods:A retrospective analysis was conducted on 158 preterm infants born between October 1，2018 and September 30，2021.All of the infants were transferred to the neonatal ward of The Third Hospital of Baogang Group within 24 hours of birth.The infants had a birth weight of less than 1 500 g and a gestational age of less than 32 weeks.These infants were used as study subjects and were divided into a bronchopulmonary dysplasia (BPD) group( n=65) and a non-BPD group ( n=93).The clinical data and nutritional intake were compared between the two groups. Results:The BPD group exhibited longer birth weight recovery and mechanical ventilation times than the non-BPD group.The BPD group also had higher rates of extrauterine growth restriction,feeding intolerance,haemodynamically significant patent ductus arteriosus and bile acid accumulation associated with parenteral nutrition than the non-BPD group ( P<0.05).The BPD group received a higher volume of parenteral nutrition in the first week after birth than the non-BPD group.However,the caloric intake per unit of parenteral nutrition,the caloric-to-nitrogen ratio,and the total intake of glucose,amino acids,and lipid emulsions were all lower in the BPD group than in the non-BPD group during the first week postnatally ( P<0.05).The breastfeeding rate,enteral caloric intake,protein-to-energy ratio,and total caloric intake were all lower in the BPD group than in the non-BPD group.It took longer for the BPD group to achieve full enteral nutrition than the non-BPD group( P<0.05). Conclusion:The early attainment of total enteral nutrition,the increased energy density of parenteral nutrition,unit parenteral nutritional calories,and an emphasis on protein-energy ratio may be measures to reduce the incidence of BPD.
