Relationship between serum prolactin and mild cognitive impairment in postmenopausal women with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.09.007
- VernacularTitle:血清泌乳素与老年女性2型糖尿病患者轻度认知障碍相关性的研究
- Author:
Jiaxuan JIANG
1
;
Zhou ZHANG
1
;
Jin WANG
1
;
Xiang XU
1
;
Yingwen MIAO
1
;
Qun DING
1
;
Congcong YU
1
;
Yinjiao HOU
1
;
Shihua CHEN
1
;
Yan BI
1
Author Information
1. 210008 南京大学医学院附属鼓楼医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Menopause;
Prolactin;
Cognitive impairment
- From:
Chinese Journal of Diabetes
2025;33(9):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between prolactin and mild cognitive impairment(MCI)in postmenopausal women with type 2 diabetes mellitus(T2DM).Methods A total of 319 postmenopausal women with T2DM who were hospitalized in the Department of Endocrinology,Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University were enrolled in this study from August 2016 to October 2023.All the patients were divided into two groups according whether they had MCI:T2DM group(n=161)and MCI group(n=158).Differences in clinical characteristics were compared between the two groups.Pearson correlation was used to analyze the correlation between sex hormones and cognitive domains,and Logistic regression analysis was used to evaluate the influencing factors for MCI development.Results Serum prolactin levels were significantly lower in the MCI group than in the T2DM group[(5.5±2.1)vs(7.2±2.9)μg/L,P<0.05].Serum prolactin level was positively correlated with mini-mental state examination score,Montreal cognitive assessment score,immediate memory score,visuopatial constructional score,attention score and hippocampal volume(P<0.05),and negatively correlated with processing speed test(time)and executive function test(time)(P<0.05).Logistic regression analysis demonstrated that serum prolactin level was an influencing factor for the risk of MCI in postmenopausal women with T2DM(OR 0.715,95%CI 0.605～0.845,P<0.01).Conclusions The decrease of serum prolactin level is associated with an increased risk of MCI in postmenopausal women with T2DM.
