Study of brain structure and functional connectivity changes in patients with type 2 diabetes mellitus and mild cognitive impairment by multimodal magnetic resonance imaging
10.3969/j.issn.1006-6187.2025.09.005
- VernacularTitle:以多模态磁共振成像探讨2型糖尿病轻度认知障碍患者脑结构及其功能连接病理改变的研究
- Author:
Hui ZENG
1
;
Ying LIU
1
;
Keranmu NUERBIYA
1
Author Information
1. 830063 乌鲁木齐,新疆医科大学第二附属医院医学影像科
- Publication Type:Journal Article
- Keywords:
Multimodal magnetic resonance imaging;
Diabetes mellitus,type 2;
Cognitive impairment;
Functional connection
- From:
Chinese Journal of Diabetes
2025;33(9):660-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of brain structure and functional connectivity by multimodal magnetic resonance imaging(MRI)in patients with type 2 diabetes mellitus(T2DM)and mild cognitive impairment(MCI).Methods A total of 120 patients with T2DM who were treated in the our hospital were enrolled in this study from April 2023 to April 2024.All the patients were divided into simple T2DM group(n=62)and MCI group(n=58)according to whether they were complicated with MCI.The general data and cognitive function related indicators were compared between the two groups,and the volume of MRI subcortical structures were analyzed.The fractional amplitude of low-frequency fluctuation(fALFF)values were compared between the two groups,and the brain regions with different fALFF values were used as seed points for voxel-based functional connectivity analysis.Pearson correlation analysis was used to analyze the correlation between MRI subcortical structure volume and abnormal functional connectivity brain regions and cognitive function in T2DM patients with MCI.Results Connection test A(TMT-A),TMT-B scores and bilateral temporal angle width of ventricles were higher,while Dorsal number span test(FDST),dorsal number span test(BDST),Wechsler adult intelligence scale(WAIS-RC)arithmetic,WAIS-RC knowledge,Montreal cognitive assessment scale(MoCA)score,bilateral caudate nucleus,putamen,hippocampal volume and subcutaneous gray matter volume were lower in MCI group than in T2DM group(P<0.05).The fALFF values increased in the left pericallosal cortex,right lingual gyrus,corpus callosum and right medial and parascingulate gyrus,while fALFF values decreased in the right inferior temporal gyrus,fusiform gyrus,left suboccipital gyrus,left parietal gyrus,left anterior cuneiform lobe,left parietal lobule and left supplementary motor area.Whole brain voxel functional connectivity analysis showed that the functional connectivity of right inferior temporal gyrus and left inferior parietal gyrus was stronger,while the functional connectivity of right lingual gyrus was weaker in MCI group than in T2DM group.Pearson correlation analysis showed that FDST,BDST,WAIS-RC arithmetic,WAIS-RC knowledge,and MoCA score were positively correlated with bilateral caudate nucleus,putamen nucleus,hippocampus volume,subcortical gray matter volume,and right inferior temporal gyrus and left inferior parietal gyrus functions(P<0.05),and negatively correlated with temporal angle width of bilateral ventricles and right superior frontal gyrus function(P<0.05).TMT-a and TMT-B scores were positively correlated with bilateral temporal angle width and right superior frontal gyrus function(P<0.05),and negatively correlated with bilateral caudate nucleus,putamen nucleus,hippocampus volume,subcortical gray matter volume,right inferior temporal gyrus and left inferior parietal gyrus function(P<0.05).Conclusions The volume of subcortical structures is changed in patients with T2DM and MCI,and there are multiple brain regions with abnormal functional connectivity.These alterations demonstrate varying degrees of correlation with MCI,providing partial insight into its neuropathological basis.
