The impact of human herpesvirus on prognostic outcomes in pediatric drug-induced hypersensitivity syndrome
10.3760/cma.j.issn.1673-4912.2025.10.003
- VernacularTitle:人类疱疹病毒对儿童药物超敏反应综合征预后的影响
- Author:
Lei JIAO
1
;
Yang WANG
1
;
Yuan LIANG
1
;
Zigang XU
1
;
Lin MA
1
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院皮肤科，儿科重大疾病研究教育部重点实验室，北京 100045
- Publication Type:Journal Article
- Keywords:
Human herpesvirus;
Drug-induced hypersensitivity syndrome;
Drug reaction with eosinophilia and systemic symptom;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(10):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the detection rate of human herpesvirus（HHV）in children with drug-induced hypersensitivity syndrome（DIHS）and to analyze the impact of HHV on the prognosis of DIHS.Methods:This study included a retrospective analysis of clinical data from hospitalized patients diagnosed with DIHS at the Department of Dermatology at Beijing Children's Hospital between January 2009 and December 2023 who underwent peripheral blood HHV-DNA testing.The positive rates of the following HHV types were analyzed:epstein-barr virus,cytomegalovirus,HHV-6,and HHV-7.The clinical features,disease severity,course,and prognosis were then compared between HHV-positive and HHV-negative children.Results:Of the 81 patients enrolled，46（56.8%）tested positive for at least one type of HHV-DNA.The positive detection cases of epstein-barr virus，cytomegalovirus，HHV-6，and HHV-7 were 16（19.8%）cases，9（11.1%）cases，25（30.9%）cases，and 8（9.9%）cases，respectively.Compared with the HHV-negative group,the HHV-positive group exhibited significantly higher incidences of facial/limb edema,severe disease,and a RegiSCAR score ≥6( P<0.05).Furthermore,the HHV-positive group experienced significantly longer durations of fever,skin rash,liver injury,total disease course,and treatment period ( P<0.05). Conclusion:HHV-6 is the most frequently detected herpesvirus among children with DIHS.HHV positivity is significantly associated with greater disease severity and a prolonged clinical course in pediatric DIHS patients.
