Research progress on the toxic effects of free bilirubin on the nervous system
10.3760/cma.j.issn.1673-4912.2025.11.010
- VernacularTitle:游离胆红素对神经系统毒性作用研究进展
- Author:
Yan LI
1
;
Jiujun LI
1
Author Information
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
- Publication Type:Journal Article
- Keywords:
Free bilirubin;
Newborns;
Bilirubin encephalopathy;
Treatment;
Prevention
- From:
Chinese Pediatric Emergency Medicine
2025;32(11):854-857
- CountryChina
- Language:Chinese
-
Abstract:
Bilirubin is an important metabolite in the human body，which mainly includes conjugated bilirubin and unconjugated bilirubin.Unconjugated bilirubin plays an important role in the pathogenesis of neonatal bilirubin encephalopathy，and unconjugated bilirubin includes bilirubin bound to albumin and free bilirubin not bound to albumin.Free bilirubin has lipophilic property and can freely infiltrate brain cells through the blood-brain barrier，causing irreversible damage to neonatal brain cells.This review mainly summarized the mechanism of nerve damage caused by free bilirubin，so as to provide clinical ideas for the prevention and treatment of neonatal bilirubin encephalopathy.
