Predictive value of the ratio of neutrophils to lymphocytes in infants with retinopathy of prematurity
10.3760/cma.j.issn.1673-4912.2025.10.002
- VernacularTitle:血液中性粒细胞与淋巴细胞比值早期预测早产儿视网膜病的临床研究
- Author:
Hongxiang GUO
1
;
Jing CHEN
1
;
Lijun LIU
1
;
Xiuyong CHENG
1
;
Qingfei HAO
1
Author Information
1. 郑州大学第一附属医院新生儿科 450000
- Publication Type:Journal Article
- Keywords:
Retinopathy of prematurity;
Preterm infant;
Neutrophil to lymphocyte ratio
- From:
Chinese Pediatric Emergency Medicine
2025;32(10):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of the neutrophil-to-lymphocyte ratio（NLR）in early prediction of retinopathy of prematurity（ROP）.Methods:The medical records of 325 preterm infants with a gestational age <32 weeks who were admitted to the Neonatology Department of the First Affiliated Hospital of Zhengzhou University from January 1,2019 to December 31,2019 were retrospectively reviewed.The complete blood cell results at 7-10 days of age were collected，including white blood cell，neutrophil，lymphocyte，monocyte，and platelet counts.The NLR，lymphocyte-to-monocyte ratio（LMR），and platelet-to-lymphocyte ratio（PLR）were calculated.Logistic regression analysis was used to assess the risk factors associated with ROP.The receiver operating characteristic curve was performed to evaluate the value of NLR in the early prediction of ROP.Results:A total of 325 infants were involved,including 110（33.8%）with ROP and 215（61.2%）without ROP.The gestational age，birth weight，platelet count，lymphocyte count，and LMR were significantly lower in the ROP group（ P<0.05），whereas the neutrophil count and NLR were found to be significantly higher（ P<0.05）.Multivariate Logistic regression analysis revealed that small gestational age，low birth weight,and high NLR were major risk factors for the development of ROP.The sensitivity and specificity of NLR in early predicting ROP were 90.1% and 74.4%，respectively. Conclusion:The NLR at the first week after birth can serve as a simple method for early prediction of the development of ROP.
