Research progress on modulation of the PI3K/AKT signaling pathway in the treatment of Alzheimer's disease with traditional Chinese medicine
10.3969/j.issn.1671-7856.2025.09.016
- VernacularTitle:中医药调控PI3K/AKT信号通路治疗阿尔茨海默病的研究进展
- Author:
Yuan TANG
1
;
Yonglin LIU
;
Wen ZHANG
;
Jian SHAO
;
Lingyu YANG
;
Yiguang LI
;
Jie CHEN
Author Information
1. 江西中医药大学药学院,南昌 330000;江中药业股份有限公司,南昌 330000
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
PI3K/AKT signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Comparative Medicine
2025;35(9):164-178
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is the most common neurodegenerative disorder worldwide,characterized primarily by cognitive impairment and memory dysfunction.Its pathological mechanisms involve the toxic accumulation of amyloid β-protein(Aβ),hyperphosphorylation of Tau protein leading to neurofibrillary tangles,mitochondrial dysfunction,synaptic impairment,cholinergic system dysfunction,neuroinflammation,and oxidative stress.Current clinical treatments for AD include acetylcholinesterase inhibitors and N-methyl-D-aspartate antagonists,which can improve cognitive function but fail to slow disease progression and often have side effects.Research indicates that traditional Chinese medicine(TCM)may regulate the phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT)signaling pathway,promoting neuronal survival,inhibiting neuroinflammation,reducing oxidative stress,preventing apoptosis,and decreasing Aβ deposition,thus improving the symptoms of AD.This review summarizes the mechanisms by which individual TCM components,extracts,and formulas may regulate the PI3K/AKT pathway in the treatment of AD,with the aim of providing a theoretical foundation for the application of TCM in AD therapy.
