Research progress on the regulation and treatment of Parkinson's disease via the AMPK signaling pathway
10.3969/j.issn.1671-7856.2025.09.013
- VernacularTitle:AMPK信号通路在帕金森病调控及治疗中的研究进展
- Author:
Chenfeng SUN
1
;
Binbin REN
Author Information
1. 河南中医药大学康复医学院,郑州 450046;河南中医药大学第一附属医院康复中心,郑州 450000
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
AMP-activated protein kinase;
signaling pathway;
neuroprotective effects;
mitochondrial function
- From:
Chinese Journal of Comparative Medicine
2025;35(9):134-144
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD),the second most common neurodegenerative disorder,involves dopaminergic neuron degeneration,abnormal α-synuclein aggregation,and energy metabolic disruption.AMP-activated protein kinase(AMPK),a key cellular energy metabolic regulator,has multiple roles in PD progression.This paper explores the structure and function of AMPK and its regulatory mechanisms in PD,including its roles in modulating neuronal energy metabolism,mediating mitochondrial function,inhibiting oxidative stress,inducing autophagy,and regulating neuroinflammation and apoptosis.Potential AMPK-based PD therapies are also reviewed,including natural products(e.g.,resveratrol,curcumin),gene therapy,and targeted delivery systems,while noting the need to precisely control the dual effects of AMPK(e.g.,overactivation causes energy stress).Future research should focus on clarifying interactions between AMPK and other pathways(e.g.,SIRT1 and NF-κB)and improving the spatiotemporal specificity of targeted treatments for clinical translation.This study offers crucial theoretical support for understanding mechanisms underlying PD and developing AMPK-targeted therapies.
