A study on the technical comparison and pedagogical application of an arrhythmia model based on barium chloride-induced rabits and ouabain-induced guinea pigs
10.3969/j.issn.1671-7856.2025.09.009
- VernacularTitle:基于家兔氯化钡法与豚鼠哇巴因法的心律失常模型技术比较和教学应用研究
- Author:
Yuliang RAO
1
;
Shulan MA
1
;
Yadong ZHANG
1
;
Yufeng YAN
1
Author Information
1. 复旦大学基础医学国家级实验教学示范中心,上海 200032
- Publication Type:Journal Article
- Keywords:
arrhythmia;
experimental teaching;
BaCl2 model;
ouabain model;
animal model
- From:
Chinese Journal of Comparative Medicine
2025;35(9):91-98
- CountryChina
- Language:Chinese
-
Abstract:
Animal models of cardiac arrhythmia are important tools for analyses of antiarrhythmic drug mechanisms and medical laboratory teaching.In this study,two major models,namely,barium chloride-induced arrhythmia in rabbits and ouabain-induced arrhythmia in guinea pigs,were systematically compared in terms of technical principles,modeling method,and indexes.By optimizing electrocardiographic parameters,standardizing arrhythmia grading criteria,and introducing quantitative analysis method,we revealed differences between the two models in terms of ion channel mechanisms,drug targets,and applicability to teaching.The barium chloride model was characterized by rapidly induced ventricular arrhythmia,which is suitable for the observation of acute drug efficacy.The ouabain model simulated the development of progressive arrhythmia,which is suitable for the study of the preventive effects of anti-arrhythmic drugs.This study provides a technical reference for the selection of arrhythmia models,optimization process,and mechanistic analyses in medical experimental teaching and is of great significance for improving the electrophysiology experimental skills of medical students.
