Research progress on mesenchymal stem cell-derived extracellular vesicles and Alzheimer's disease
10.3969/j.issn.1671-7856.2025.09.011
- VernacularTitle:间充质干细胞外泌体与阿尔茨海默病研究进展
- Author:
Sirui LIU
1
;
Yadong WANG
;
Zhiyi CHEN
;
Jingxian HAN
;
Xuezhu ZHANG
Author Information
1. 天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 300380
- Publication Type:Journal Article
- Keywords:
exosomes;
mesenchymal stem cells;
Alzheimer's disease
- From:
Chinese Journal of Comparative Medicine
2025;35(9):113-121
- CountryChina
- Language:Chinese
-
Abstract:
With population aging worldwide,Alzheimer's disease(AD)has become a serious human health issue.Owing in part to the complexity of the pathogenesis of AD,effective therapeutic options are lacking.Mesenchymal stem cell-derived exosomes(MSC-Exos)have powerful regenerative properties and repair functions,providing a new direction for treatment.They are donor-derived,easily stored,natural carriers,with low immunogenicity and a low risk of tumor formation.They have shown great potential in the treatment of AD and post-treatment rehabilitation.This article introduces the pathological mechanisms of AD and characteristics of MSC-Exos,provides a detailed review of the roles of MSC-Exos in the treatment of AD,including anti-inflammatory effects,immunomodulatory effects,and related signaling pathway modulation,and summarizes recent research progress,with the aim of providing a basis for the development of novel therapeutic approaches to AD.
