Analysis of clinical diagnosis,treatment and prognostic factors in 75 cases of urachal carcinoma
10.3969/j.issn.1009-8291.2025.09.002
- VernacularTitle:脐尿管癌75例临床诊疗及预后因素分析
- Author:
Yong ZHANG
1
;
Lingang CUI
1
;
Penghui YUAN
1
;
Tianyu LYU
1
;
Jiahao CUI
1
;
Zhuo ZHAO
1
;
Qingjun MENG
1
Author Information
1. 郑州大学第一附属医院泌尿外科,河南郑州 450052
- Publication Type:Journal Article
- Keywords:
urachal carcinoma;
adenocarcinoma of colon;
partial cystectomy;
Sheldon staging;
postoperative recurrence;
CK7
- From:
Journal of Modern Urology
2025;30(9):733-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnosis,treatment and prognostic factors of urachal carcinoma(UrC),aiming to provide reference for the standardized diagnosis and treatment of this disease.Methods A retrospective analysis was conducted on the clinical data of 75 UrC patients confirmed with postoperative pathology treated in our hospital during Mar.2010 and Mar.2023.All patients underwent surgical treatment,and 35 received postoperative chemotherapy.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors.Kaplan-Meier curves were adopted to calculate the cumulative survival rates and overall survival(OS).Results Among the 75 patients,the male to female ratio was 2.8∶1 and the mean age was(58.4±2.2)years.Median follow-up was 60 months and median OS was 48 months.The 3-year survival rate was 67.3％and the 5-year survival rate was 38.8％.There were 19 cases(25.3％)of CK7 positive,60 cases(80.0％)of Sheldon stage Ⅲ and above,and 26 cases(34.7％)of postoperative recurrence.CK7 positive(P=0.001),Sheldon staging Ⅲ+Ⅳ(P=0.005)and postoperative recurrence(P=0.003)were independent prognostic factors.Conclusion Urachal carcinoma is a rare malignant tumor in males with occult onset.CK7 positive,Sheldon staging and postoperative recurrence were independent prognostic factors of this disease.
