The correlation between serum phosphate disorder and the prognosis of sepsis in children
10.3760/cma.j.issn.1673-4912.2025.03.002
- VernacularTitle:血清磷酸盐紊乱与儿童脓毒症预后的相关性研究
- Author:
Yan JIANG
1
;
Weikai WANG
;
Yanxia WANG
;
Xin WANG
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730030
- Publication Type:Journal Article
- Keywords:
Phosphate;
Mortality rate;
Sepsis;
Septic shock;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(3):170-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between serum phosphate levels and poor prognosis in children with sepsis.Methods:A retrospective cohort study was conducted to the children with sepsis or septic shock admitted to Gansu Provincial Maternal and Child Health Hospital from 2017 to 2023.Based on the pretreatment serum phosphate values of the children，they were divided into hypophosphatemia group，normal blood phosphate group，and hyperphosphatemia group.The clinical data of characteristics,length of hospital stay and regression of septic children in different serum phosphate groups were recorded,and the prognosis of the children was followed up 3 months after discharge from the hospital.The relationship between serum phosphate levels and prognosis of sepsis in children was explored using univariate and multivariate Logistic regression analysis.Results:A total of 200 children aged 0-14 years diagnosed with sepsis were included,of whom 100 cases (50.0%) had hypophosphatemia,43 cases (21.5%) had hyperphosphatemia,and 57 cases (28.5%) had normophosphate status (normophosphate group).Compared with the normophosphate and hypophosphate groups,the proportion of critically ill patients in the pediatric critical illness score of the hyperphosphatemia group was significantly increased.The incidence of septic shock increased by 5.5% and 24.1%,respectively（ P=0.032）.The duration of mechanical ventilation was significantly longer than the other two groups ( P=0.013).Multivariate Logistic regression analysis showed that the 3-month post-discharge mortality rate ( RR=6.960，95% CI 1.580-30.667， P=0.010) and total mortality ( RR=6.880,95% CI 2.038-23.233, P=0.002) of septic children in the hyperphosphatemia group were 6.960 and 6.880 times higher than those in the normophosphate group,and the differences were statistically significant. Conclusion:Elevated serum phosphate levels may be an early warning factor for poor prognosis of sepsis in children,and PICU healthcare professionals should pay attention to this indicator and take timely diagnostic and therapeutic measures to improve the prognosis.
