Research progress on the timing of continuous renal replacement therapy in children with septic shock
10.3760/cma.j.issn.1673-4912.2025.02.012
- VernacularTitle:脓毒性休克患儿行持续性肾脏替代治疗时机选择的研究进展
- Author:
Jinming ZHANG
1
;
Xiaoxu YIN
;
Lijie WANG
Author Information
1. 中国医科大学附属盛京医院儿童急诊与重症医学科，沈阳 110004
- Publication Type:Journal Article
- Keywords:
Sepsis;
Septic shock;
Continuous renal replacement therapy;
Acute kidney injury;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(2):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis and septic shock are common emergencies in pediatric intensive care unit with high mortality.The existence of sepsis-related acute kidney injury and multiple organ dysfunction syndrome further increases the risk of death in children with sepsis.Currently，continuous renal replacement therapy（CRRT）is employed to continuously remove toxins and excess fluid from the body，helping to maintain hemodynamic stability and fine-tuning electrolyte and acid-base balance.It has emerged as an important adjuvant therapy for sepsis and septic shock.Although the absolute indications for CRRT initiation have been clearly defined in domestic and foreign guidelines，there is no consensus on the optimal timing of CRRT initiation in children with septic shock.Both early and late CRRT initiation have their own advantages and disadvantages.
