Clinical characteristics of 12 children with infective endocarditis without congenital heart disease
10.3760/cma.j.issn.1673-4912.2025.02.011
- VernacularTitle:12例无先天性心脏病儿童感染性心内膜炎临床特征分析
- Author:
Chenmeng ZHANG
1
;
Jiandong WANG
1
;
Jiechao NIU
1
;
Huaili WANG
1
Author Information
1. 郑州大学第一附属医院PICU 450000
- Publication Type:Journal Article
- Keywords:
Infective endocarditis;
Congenital heart disease;
Clinical characteristics;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of infective endocarditis（IE）in children without congenital heart disease（CHD）.Methods:The clinical data of 51 children with IE admitted to the Department of Pediatrics at the First Affiliated Hospital of Zhengzhou University from February 2014 to February 2024 were retrospectively analyzed.According to whether they had CHD，they were divided into non-CHD group（12 cases）and CHD group（39 cases）.The clinical manifestations，laboratory tests，etiology results，efficacy and prognosis of the non-CHD group were analyzed.Results:The proportion of skin pustule found in non-CHD group (2/12) was significantly higher than that in CHD group(0/39)( P=0.041).Compared with CHD group, the common pathogen in non-CHD group was Staphylococcus aureus( P=0.002).There were no statistically significant differences in age, gender, symptoms, laboratory tests, ultrasound detection rate and distribution of vegetations, positive rate of blood culture, course of anti infection treatment, and mortality rate between the two groups. Conclusion:For children with IE who do not houre underlying CHD,skin pustule is an important indicator, and Staphylococcus aureus is the most common pathogen. The use of broad-spectrum antibiotics as early empirical anti infective agents is key to improve prognosis.
