Influence of Shumian Capsules Combined with Quetiapine on Negative Symptoms,Sleep Quality and Neurotransmitters in Patients with Schizophrenia
10.13241/j.cnki.pmb.2025.18.013
- VernacularTitle:舒眠胶囊联合喹硫平对精神分裂症患者阴性症状、睡眠质量及神经递质的影响
- Author:
Fei-yan CHEN
1
;
Jian-yi XU
;
Hong LIN
Author Information
1. 福建省福州市鼓楼区医院西药房 福建 福州 350001
- Publication Type:Journal Article
- Keywords:
Shumian Capsules;
Quetiapine;
Schizophrenia;
Negative symptoms;
Sleep quality;
Neurotransmitters
- From:
Progress in Modern Biomedicine
2025;25(18):2973-2980
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This prospective study is conducted to explored the influence of Shumian Capsules combine with quetiapine on negative symptoms,sleep quality and neurotransmitters in patients with schizophrenia.Methods:50 patients with schizophrenia admitted to Fuzhou Gulou District Hospital of Fujian Province from April 2022 to May 2024 were retrospectively selected as the study group.According to the principle of 1∶1 matching cases,50 patients with schizophrenia in the same period were selected as the reference group.Reference group received quetiapine treatment,while study group was treated with Shumian capsules on the basis of the reference group.Negative symptom scale(SANS),positive and negative symptom scale(PANSS),Pittsburgh sleep quality index(PSQI),social-skills for psychiatric inpatients(SSPI),treatment emergent symptom scale(TESS),self-rating anxiety scale SAS),self-rating depression scale(SDS)score,neurotransmitter levels[γ-aminobutyric acid(GABA),brain-derived neurotrophic factor(BDNF),glutamic acid(Glu)and the occurrence of adverse reactions were compared between the two groups.Results:The scores of SANS,PANSS,PSQI,TESS,SAS,SDS and Glu levels decreased 4 weeks and 8 weeks after treatment in both groups,and study group were lower than those in reference group,SSPI score and GABA and BDNF levels increased,and study group were higher than those in the reference group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Shumian Capsules combined with quetiapine can effectively improve negative symptoms,sleep quality and neurotransmitters in patients with schizophrenia,and have good safety.
