Mechanism of tumor-associated macrophages in mediating drug resistance in lung cancer and research progress of traditional Chinese medicine intervention
10.3969/j.issn.1000-484X.2025.07.017
- VernacularTitle:肿瘤相关巨噬细胞介导肺癌耐药的机制及中药干预研究进展
- Author:
Tianqi WANG
1
;
Jinchan XIA
;
Huahui ZENG
;
Yingxue XU
;
Zhonghui XUE
;
Mengjiao SU
;
Jiale HAN
Author Information
1. 河南中医药大学医学院,郑州 450046
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Tumor-associated macrophages;
Drug-resistance;
Traditional Chinese medicine
- From:
Chinese Journal of Immunology
2025;41(7):1656-1664
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most prevalent malignant tumors,which incidence and mortality rates increasing annually.Development of drug resistance is a primary factor contributing to treatment failure.Tumor-associated macrophages(TAMs),as key immune cells within tumor microenvironment(TME),play a significant role in the emergence and progression of drug resistance in tu-mors.TAMs can polarize into two distinct subtypes,M1 and M2,in response to diverse signaling stimuli.Research indicates that M2 TAMs are closely associated with poor prognoses in lung cancer,facilitating drug resistance through mechanisms such as promoting angiogenesis,enabling immune evasion,inducing stem cell-like characteristics in tumors,modulating relevant signaling pathways,and secreting cytokines.Traditional Chinese medicine(TCM)is characterized by its multi-target approach and minimal toxic side effects,it has been shown to enhance tumor sensitivity to drugs,slow malignant progression,and extend patient survival.This paper reviews the relationship between TAMs and lung cancer drug resistance while summarizing current research on TCM and their active components that regulate TAM activity to mitigate drug resistance in lung cancer,aiming to provide new insights for targeting TAMs in this context.
