High-dose glucocorticoid therapy for pediatric acute necrotizing encephalopathy
10.3760/cma.j.issn.1673-4912.2025.02.003
- VernacularTitle:大剂量糖皮质激素在儿童急性坏死性脑病中的应用
- Author:
Kechun LI
1
;
Suyun QIAN
1
;
Chaonan FAN
1
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院重症医学科 100045
- Publication Type:Journal Article
- Keywords:
Acute necrotizing encephalopathy;
Glucocorticoids;
Pulse therapy;
Prognosis
- From:
Chinese Pediatric Emergency Medicine
2025;32(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Acute necrotizing encephalopathy（ANE）is a rare post-infectious neurological disease primarily affecting children under 5 years old，with a high mortality and disability rate.Early administration of high-dose glucocorticoids is widely recognized as crucial for optimal efficacy of treatment.However，standardized guidance is lacking，and the optimal dosage as well as timing for administration require validation in larger patient populations.Additionally，combination therapies involving intravenous immunoglobulin，plasmapheresis，tocilizumab，and antiviral treatments may enhance efficacy and reduce mortality rates and neurological sequelae.This review summarized the current application status of high-dose glucocorticoid therapy for ANE in recent years and analyzed the differences in efficacy among different types and doses of glucocorticoids,as well as different timing of administration,with the aim of providing valuable references for optimizing treatment regimens in the future.
