The Role of Intestinal Endotoxemia in the Development of Hepatopulmonary Syndrome in Rats
10.13241/j.cnki.pmb.2025.18.003
- VernacularTitle:肠源性内毒素血症在大鼠肝肺综合征形成中的作用研究
- Author:
Xia LI
1
;
Hao CHEN
1
;
Hai-yang YANG
1
;
Yu-zhuo WANG
1
;
Li-guo WANG
1
Author Information
1. 哈尔滨医科大学附属第四医院 黑龙江哈尔滨 150000
- Publication Type:Journal Article
- Keywords:
Hepatopulmonary Syndrome;
Intestinal endotoxemia;
TNF-α;
IL-6
- From:
Progress in Modern Biomedicine
2025;25(18):2897-2902
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role and mechanism of intestinal endotoxemia in the development of hepatopulmonary syndrome in rats.Methods:Rats were randomly divided into Experimental Group(N=10)and Control Group(N=10),and the rat model of Hepatopulmonary Syndrome was established by common bile duct ligation(CBD),and the contents of endotoxin,TNF-α and IL-6 were measured.Rat lung microvascular endothelial cells were isolated and cultured in vitro.Endotoxin induced the activation and proliferation of these cells,and the levels of TNF-α and IL-6 were detected.Results:The level of endotoxin in rats with hepatopulmonary syndrome was significantly elevated,which induced the production of TNF-α and IL-6,causing pulmonary vasodilation and hypoxemia.Conclusions:Intestinal endotoxemia plays an important role in the development of Hepatopulmonary Syndrome,and its possible mechanism is to induce pulmonary microvascular endothelial cells to produce a variety of inflammatory cytokines and to promote the development of pulmonary vasodilation and Hepatopulmonary Syndrome.It provides key experimental evidence and potential targets for the prevention and treatment strategies of hepatopulmonary syndrome.
