Study on the Relationship between Monocyte-Lymphocyte Ratio,Modified Glasgow Prognostic Score and the Prognosis of Patients with Advanced Gastric Cancer after Radical Gastrectomy
10.13241/j.cnki.pmb.2025.18.012
- VernacularTitle:单核细胞和淋巴细胞比值、改良格拉斯哥预后评分与进展期胃癌患者胃癌根治术后预后的关系研究
- Author:
Zhi-qiang LI
1
;
Jun CHEN
;
Guo-chong DING
Author Information
1. 南平市第二医院胃肠疝外科 福建南平 354200
- Publication Type:Journal Article
- Keywords:
Advanced gastric cancer;
Radical gastrectomy;
Monocyte-lymphocyte ratio;
Modified Glasgow prognostic score;
Prognosis
- From:
Progress in Modern Biomedicine
2025;25(18):2965-2972
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between monocyte-lymphocyte ratio(MLR),modified Glasgow prognostic score(mGPS)and the prognosis of patients with advanced gastric cancer after radical gastrectomy.Methods:A retrospective analysis was conducted on the data of 106 patients with advanced gastric cancer who underwent radical gastrectomy in our hospital from April 2018 to April 2021,the patients were followed up for 3 years after the operation.MLR and mGPS scores of patients with different clinical characteristics were compared.The Kaplan-Meier method was used to analyze the survival differences of patients in different MLR and mGPS groups,and the survival curves were plotted.The Cox regression model was used to analyze variables such as clinical characteristics,laboratory indicators,MLR and mGPS scores,and to screen out the independent factors affecting the prognosis of patients.The receiver operating characteristic(ROC)curve was constructed to evaluate the efficacy of MLR,mGPS scores and their combination in predicting poor prognosis efficiency of patients,and the area under the curve(AUC),sensitivity and specificity were calculated.Results:MLR and mGPS scores were correlated with tumor TNM stage,degree of differentiation,tumor diameter,lymph node metastasis and postoperative chemotherapy(P＜0.05).The 3-year survival rates of the MLR ≥0.3 group and mGPS ≥ 1 group were 45.20％and 50.00％respectively,which were much lower than those in the low MLR group and mGPS group(78.40％and 82.40％,P＜0.05).The survival rate in the high-risk group(MLR ≥0.3 and mGPS ≥ 1)was 29.41％,significantly lower than those in the medium and low-risk groups(P＜0.05).Cox multivariate analysis showed that high clinical stage,lymph node metastasis,high degree of differentiation,high MLR and high mGPS scores were independent risk factors affecting the prognosis of patients.ROC curve showed that the AUC of MLR and mGPS scores alone in predicting poor prognosis of patients was 0.756 and 0.842,respectively,the AUC of combination detection the two was 0.909,the predictive efficacy of the combination detection was significantly better than that of the single detection.Conclusion:Elevated MLR and mGPS scores can be used as independent prognostic indicators after advanced gastric cancer,the combination in predicting is helpful to provide a more accurate basis for clinical prognosis assessment.
